反应详情

An acetone (5 ml) suspension of 3,5-difluoro-4-(2,2,2-trifluoro-1,1-dimethylethyl)phenol (227 mg, 0.95 mmol), ethyl bromoacetate (174 mg, 1.0 mmol) and potassium carbonate (261 mg, 1.9 mmol) was stirred at reflux for 1 hour. Then, the reaction was quenched with water and the product was extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtrated and evaporated to furnish 267 mg (87% yield) of the title compound as colorless oil.

1. temperatureat reflux for 1 hour
2. customThen, the reaction was quenched with water
3. extractionthe product was extracted with ethyl acetate
4. dry with materialThe organic layer was dried over sodium sulfate
5. filtrationfiltrated
6. customevaporated