HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine Hydrochloride → HCID 178513081, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine Hydrochloride | HCID 5742 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl chloride | HCID 11231811 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178513081 | HCID 178513081 | — |
Reaction Steps
combining guanidine hydrochloride and sodium hydroxide with a suspension of 5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole4-carboxylic acid chloride in tetrahydrofuran at a temperature of about −10° C. to about 10° C. for about 1 hour to about 3 hours to form N-(5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole4-carbonyl)-guanidine; and
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06441176B1 |
| Source dataset | uspto-grants-2002_08 |
| ORD ID | ord-470f417b3b7b47578eb72dd6ebb31ab6 |
| Source note | uspto-grants-2002_08 |