Guanidine Hydrochloride → HCID 178513081, compound

HRID 2306008Notes

Reaction equation

HRID 2306008 reaction equation
Cl.[NH2:2][C:3]([NH2:5])=[NH:4].[OH-].[Na+].[CH:8]1([C:11]2[N:15]([C:16]3[CH:25]=[CH:24][CH:23]=[C:22]4[C:17]=3[CH:18]=[CH:19][CH:20]=[N:21]4)[N:14]=[CH:13][C:12]=2[C:26](Cl)=[O:27])[CH2:10][CH2:9]1>O1CCCC1>[CH:8]1([C:11]2[N:15]([C:16]3[CH:25]=[CH:24][CH:23]=[C:22]4[C:17]=3[CH:18]=[CH:19][CH:20]=[N:21]4)[N:14]=[CH:13][C:12]=2[C:26]([NH:4][C:3]([NH2:5])=[NH:2])=[O:27])[CH2:10][CH2:9]1

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 14798Sodium HydroxideHCID 112318115-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl chloride

Product 1

HCID 178513081HCID 178513081, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

combining guanidine hydrochloride and sodium hydroxide with a suspension of 5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole4-carboxylic acid chloride in tetrahydrofuran at a temperature of about −10° C. to about 10° C. for about 1 hour to about 3 hours to form N-(5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole4-carbonyl)-guanidine; and

Sources & evidence

ORD record
ord-470f417b3b7b47578eb72dd6ebb31ab6
Source dataset
uspto-grants-2002_08
Patent number
US06441176B1

Reaction notes

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