反应详情

温度

80 °C

To a 3 L three neck round bottom flask equipped with a mechanical stirrer and teflon-coated thermocouple was added compound (13) (1672 g, 9 mol), isobutyric acid (264 g, 1.5 mol), and compound (12) (1050 g, 5.76 mol). The reaction mixture was heated to 80° C. for 12 h and the progress of the reaction monitored by 1H NMR. The reaction mixture was cooled to 20° C., diluted with EtOAc (1 L) and sequentially washed with water (2×1 L), saturated NaHCO3 (1×2 L), and water (1 L). The organic phase was separated and concentrated under reduced pressure to afford the title compound (11) (905 g, 3.9 mol, 65% yield) as a colorless liquid. 1H NMR (CDCl3, 400 MHz): δ 1.0 (d, 6H), 1.2 (dd, 6H), 2.05 (m, 1H), 2.35 (s, 3H), 2.6 (m, 1H), 6.7 (d, 1H).

1. temperatureThe reaction mixture was cooled to 20° C.
2. washsequentially washed with water (2×1 L), saturated NaHCO3 (1×2 L), and water (1 L)
3. customThe organic phase was separated
4. concentrationconcentrated under reduced pressure