4-(Trifluoromethoxy)phenylacetonitrile → 2-[4-(Trifluoromethoxy)phenyl]ethan-1-amine

HRID 2306161Notes

Reaction equation

HRID 2306161 reaction equation
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]#[N:12])=[CH:6][CH:5]=1.[H][H]>[Ni]>[F:1][C:2]([F:13])([F:14])[O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][NH2:12])=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 1426764-(Trifluoromethoxy)phenylacetonitrileHCID 178418361HCID 178418361, compound

Product 1

HCID 106320402-[4-(Trifluoromethoxy)phenyl]ethan-1-amine

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

reducing the (4-trifluoromethoxyphenyl)acetonitrile using hydrogen in the presence of a nickel catalyst to form 2-(4-trifluoromethoxyphenyl)ethylamine.

Sources & evidence

ORD record
ord-90b91cab0371483486340f9482832a44
Source dataset
uspto-grants-2002_08
Patent number
US06441239B1

Reaction notes

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