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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2306161Generated: November 1, 2026

4-(Trifluoromethoxy)phenylacetonitrile → 2-[4-(Trifluoromethoxy)phenyl]ethan-1-amine

https://huagongshe.com/reaction/2306161

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethoxy)phenylacetonitrileHCID 142676—
ReactantHCID 178418361HCID 178418361—
CatalystNickelHCID 935—
Product2-[4-(Trifluoromethoxy)phenyl]ethan-1-amineHCID 10632040—

Reaction Steps

reducing the (4-trifluoromethoxyphenyl)acetonitrile using hydrogen in the presence of a nickel catalyst to form 2-(4-trifluoromethoxyphenyl)ethylamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06441239B1
Source datasetuspto-grants-2002_08
ORD IDord-90b91cab0371483486340f9482832a44
Source noteuspto-grants-2002_08