Ammonia → 4-(Trifluoromethoxy)benzyl Chloride

200 g of trifluoromethoxybenzene and 48 g of paraformaldehyde were dissolved in 500 ml of methanol, and dry hydrogen chloride gas was introduced at 60° C. for 7 hours. The waste gases were, via a reflux condenser, passed into aqueous ammonia. The reaction mixture was then poured onto 1,000 g of ice and extracted twice with in each case 300 ml of methyl tert-butyl ether. The combined extracts were washed with 100 ml of water and then with 100 ml of sodium bicarbonate solution and subsequently concentrated. The residue was distilled at 18 hPa in a spinning band column. This gave 158.8 g of 4-chloromethyl-1-trifluoromethoxybenzene as a colorless liquid (65% of theory) of b.p. 71-74° C.

1. customThe waste gases were, via a reflux condenser
2. extractionextracted twice with in each case 300 ml of methyl tert-butyl ether
3. washThe combined extracts were washed with 100 ml of water
4. concentrationwith 100 ml of sodium bicarbonate solution and subsequently concentrated
5. distillationThe residue was distilled at 18 hPa in a spinning band column

ORD record

ord-2628aaa9dcd7475d82df532624734e04

Source dataset

uspto-grants-2002_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06441239B1