Hydrochloric Acid → HCID 178499561, compound

HRID 2306191Notes

Reaction equation

HRID 2306191 reaction equation
[ClH:1].[NH:2]1[CH:6]=[C:5]([CH2:7][C:8]([OH:10])=[O:9])[N:4]=[CH:3]1.Cl.[CH:12](OC)(OC)OC>CO>[ClH:1].[NH:2]1[CH:6]=[C:5]([CH2:7][C:8]([O:10][CH3:12])=[O:9])[N:4]=[CH:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 9005Trimethyl orthoformateHCID 178479752HCID 178479752, compound

Product 1

HCID 178499561HCID 178499561, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4-imidazoleacetic acid hydrochloride (4.00 g, 24.6 mmol) in MeOH (100 mL) was saturated with HCl (g). Trimethyl orthoformate (10 mL, 91 mmol) was added and the mixture was stood at ambient temperature for 18 hours, then concentrated to dryness in vacuo to afford the titled ester as a white solid.

Workup

  1. concentrationconcentrated to dryness in vacuo

Sources & evidence

ORD record
ord-af8f935c765c43139ca76f72a7d01057
Source dataset
uspto-grants-2002_08
Patent number
US06441017B1

Reaction notes

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