HCID 70172693, compound → HCID 178454138, compound

HRID 2306257Notes

Reaction equation

HRID 2306257 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[CH:16][CH:17]=[C:18]3[C:23]=2[N:22]=[C:21]([O:24]C)[CH:20]=[CH:19]3)[C:10]1=[O:26])=[O:7])([CH3:4])([CH3:3])[CH3:2]>CC(O)=O>[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[CH:16][CH:17]=[C:18]3[C:23]=2[N:22]=[C:21]([OH:24])[CH:20]=[CH:19]3)[C:10]1=[O:26])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 70172693HCID 70172693, compound

Product 1

HCID 178454138HCID 178454138, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
120 °C

Procedure

(S)-3-(tert-Butoxycarbonylamino)-1-(2-methoxyquinolin-8-yl)-2-oxopyrrolidine, as described above in Step F, (287 mg, 0.803 mmol) and KI (240 mg, 1.44 mmol) were dissolved in AcOH (10 mL) and heated to 120° C. for 1 hour. The reaction mixture was concentrated in vacuo, to yield the above-titled compound.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-59f021395f0d4f80ab64c93e904bc553
Source dataset
uspto-grants-2002_08
Patent number
US06441017B1

Reaction notes

Loading…