Hydrochloric Acid → HCID 131723469, compound

Participants

Reaction Steps

A mixture of methyl {5-[1-(tert-butoxycarbonylamino)-1-(4-cyano-3-fluorophenyl)ethyl]imidazol-1-yl}acetate, as described above in Step C, (321 mg, 0.798 mmol) and LiOH (21.0 mg, 0.877 mmol) was stirred in THF (5 mL) and H2O (1.8 mL) at ambient temperature for 1 hour. The solution was adjusted to pH≈7 by the addition of 1.0 N aqueous HCl and then concentrated in vacuo to give the desired product.

Provenance & Evidence