Hydrochloric Acid → HCID 131723469, compound

HRID 2306278Notes

Reaction equation

HRID 2306278 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]([C:20]1[N:24]([CH2:25][C:26]([O:28]C)=[O:27])[CH:23]=[N:22][CH:21]=1)([C:11]1[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[C:13]([F:19])[CH:12]=1)[CH3:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].[Li+:30].[OH-].O.Cl>C1COCC1>[C:1]([O:5][C:6]([NH:8][C:9]([C:20]1[N:24]([CH2:25][C:26]([O-:28])=[O:27])[CH:23]=[N:22][CH:21]=1)([C:11]1[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[C:13]([F:19])[CH:12]=1)[CH3:10])=[O:7])([CH3:2])([CH3:3])[CH3:4].[Li+:30]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 91307750HCID 91307750, compound

Product 1

HCID 131723469HCID 131723469, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of methyl {5-[1-(tert-butoxycarbonylamino)-1-(4-cyano-3-fluorophenyl)ethyl]imidazol-1-yl}acetate, as described above in Step C, (321 mg, 0.798 mmol) and LiOH (21.0 mg, 0.877 mmol) was stirred in THF (5 mL) and H2O (1.8 mL) at ambient temperature for 1 hour. The solution was adjusted to pH≈7 by the addition of 1.0 N aqueous HCl and then concentrated in vacuo to give the desired product.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-c0cc26358624467cb2e9c13583d73fac
Source dataset
uspto-grants-2002_08
Patent number
US06441017B1

Reaction notes

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