Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| Reactant | 6-Hydroxy-chroman-4-one | HCID 7098944 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18433519 | HCID 18433519 | — |
Reaction Steps
A mixture of 6-hydroxy-2,3-dihydro-4H-chromen-4-one (1.65 g, 10.1 mmol), tert-butyldiphenylsilylchloride (6.87 g, 25.2 mmol), and imidazole (2.1 g, 30.3 mmol) in degassed DMF (30 mL) was heated at 60° C. for 18 hours. The solvent was removed in vacuo and the residue purified by silica gel chromatography, eluting with hexane—20% EtOAc, to yield the titled product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06441017B1 |
|---|
| Source dataset | uspto-grants-2002_08 |
|---|
| ORD ID | ord-ce6664f85f8d470cbef421f6a5817b8a |
|---|
| Source note | uspto-grants-2002_08 |
|---|
