反应详情

温度

60 °C

A mixture of 6-hydroxy-2,3-dihydro-4H-chromen-4-one (1.65 g, 10.1 mmol), tert-butyldiphenylsilylchloride (6.87 g, 25.2 mmol), and imidazole (2.1 g, 30.3 mmol) in degassed DMF (30 mL) was heated at 60° C. for 18 hours. The solvent was removed in vacuo and the residue purified by silica gel chromatography, eluting with hexane—20% EtOAc, to yield the titled product.

1. customThe solvent was removed in vacuo
2. customthe residue purified by silica gel chromatography
3. washeluting with hexane—20% EtOAc