Acetic Anhydride → N-(2-Chloro-4-iodophenyl)acetamide

HRID 2306412Notes

Reaction equation

HRID 2306412 reaction equation
[Cl:1][C:2]1[CH:8]=[C:7]([I:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:10](OC(=O)C)(=[O:12])[CH3:11]>O1CCCC1>[Cl:1][C:2]1[CH:8]=[C:7]([I:9])[CH:6]=[CH:5][C:3]=1[NH:4][C:10](=[O:12])[CH3:11]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 2829302-Chloro-4-iodoaniline

Product 1

HCID 18434368N-(2-Chloro-4-iodophenyl)acetamideYield 84%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 2-chloro-4-iodoaniline (25 g, 96.66 mmol) in tetrahydrofuran (100 mL) was cooled to 0° C. and then treated with acetic anhydride (50.6 g, 500 mmol). The reaction mixture was stirred at 0° C. for 10 min and then allowed to warm to 25° C. where it was stirred for 15 h. The reaction mixture was then concentrated in vacuo to remove tetrahydrofuran. The residue was crystallized from ether (50 mL) and hexanes (50 mL). The solids were collected and washed with hexanes to afford N-(2-chloro-4-iodo-phenyl)-acetamide (23.87 g, 84%) as a white crystalline solid: EI-HRMS m/e calcd for C8H7ClINO (M+) 295.1526, found 295.1532.

Workup

  1. temperatureto warm to 25° C. where it
  2. stirringwas stirred for 15 h
  3. concentrationThe reaction mixture was then concentrated in vacuo
  4. customto remove tetrahydrofuran
  5. customThe residue was crystallized from ether (50 mL) and hexanes (50 mL)
  6. customThe solids were collected
  7. washwashed with hexanes

Sources & evidence

ORD record
ord-c945fd2db7b543b08b3a6b42bf9df2e1
Source dataset
uspto-grants-2002_08
Patent number
US06441180B1

Reaction notes

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