2,4-Difluorobenzaldehyde → HCID 73985904, compound

HRID 2306590Notes

Reaction equation

HRID 2306590 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:13][NH2:14])=[CH:6][C:7]=1[N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1.[F:15][C:16]1[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:17]=1[CH:18]=O>Cl>[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:13][N:14]=[CH:18][C:17]2[CH:20]=[CH:21][C:22]([F:24])=[CH:23][C:16]=2[F:15])=[CH:6][C:7]=1[N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 737702,4-DifluorobenzaldehydeHCID 226099553-Chloro-6-hydrazinyl-4-(1-pyrrolidinyl)pyridazine

Product 1

HCID 73985904HCID 73985904, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

3-Chloro-6-hydrazino-4-(pyrrolidin-1-yl)pyridazine (1.06 g, 4.9 mmol) and 2,4-difluorobenzaldehyde (437 ml, 4.9 mmol) were stirred in 0.2M hydrochloric acid (30 ml) for 2 hours. The precipitated imine was then collected by filtration and dried (1.37 g, 92%). MS (ES+) 338 [MH]+, 340 [MH]+.

Workup

  1. filtrationThe precipitated imine was then collected by filtration
  2. customdried (1.37 g, 92%)

Sources & evidence

ORD record
ord-bd01c367725549d494c75fa11488732d
Source dataset
uspto-grants-2004_12
Patent number
US06828322B2

Reaction notes

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