HCID 10288183, compound → HCID 23529017, compound

HRID 2306625Notes

Reaction equation

HRID 2306625 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].ClCCl.C(OC(=O)[NH:17][CH2:18][C@@H:19]1[O:23][C:22](=[O:24])[N:21]([C:25]2[CH:30]=[CH:29][C:28]([C:31]3[S:32][CH2:33][C:34](=[S:37])[NH:35][N:36]=3)=[C:27]([F:38])[CH:26]=2)[CH2:20]1)(C)(C)C>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH2:17][CH2:18][C@@H:19]1[O:23][C:22](=[O:24])[N:21]([C:25]2[CH:30]=[CH:29][C:28]([C:31]3[S:32][CH2:33][C:34](=[S:37])[NH:35][N:36]=3)=[C:27]([F:38])[CH:26]=2)[CH2:20]1

Participants

3

Reactant 2

HCID 10288183HCID 10288183, compoundHCID 21863450Trifluoroacetic acid methylene chloride

Product 1

HCID 23529017HCID 23529017, compound

Procedure

20% Trifluoroacetic acid/dichloromethane (2 ml) is added to {3-[3-fluoro-4-(5-thioxo-5,6-dihydro-4H-[1,3,4]thiadiazin-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamic acid tert-butyl ester and the mixture is stirred at room temperature for 30 minutes. The reaction is evaporated to dryness and the trifluoroacetate salt is used directly in the next step.

Workup

  1. customThe reaction is evaporated to dryness

Sources & evidence

ORD record
ord-31dcb6254e9b422396e405bb841358bf
Source dataset
uspto-grants-2004_12
Patent number
US06828317B2

Reaction notes

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