3-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole → 1-{4-[1-(1-pyrrolidinylcarbonyl)cyclopropyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

HRID 230670Notes

Reaction equation

HRID 230670 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]([N:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)=[O:12])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[F:18][C:19]([F:30])([F:29])[C:20]1[C:28]2[CH2:27][CH2:26][CH2:25][CH2:24][C:23]=2[NH:22][N:21]=1>>[N:13]1([C:11]([C:8]2([C:5]3[CH:6]=[CH:7][C:2]([N:22]4[C:23]5[CH2:24][CH2:25][CH2:26][CH2:27][C:28]=5[C:20]([C:19]([F:18])([F:30])[F:29])=[N:21]4)=[CH:3][CH:4]=3)[CH2:10][CH2:9]2)=[O:12])[CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 28028633-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazoleHCID 577628281-{[1-(4-Iodophenyl)cyclopropyl]carbonyl}pyrrolidine

Product 1

HCID 248271421-{4-[1-(1-pyrrolidinylcarbonyl)cyclopropyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

Procedure

The title compound was prepared from 1-{[1-(4-iodophenyl)cyclopropyl]carbonyl}pyrrolidine and 3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole using a similar procedure to that described for Example 19.

Sources & evidence

ORD record
ord-fae2ec22b498425e9bc3dd8cf284f9f9
Source dataset
uspto-grants-2009_07
Patent number
US07566735B2

Reaction notes

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