Hydrochloric Acid → 239113-23-6

HRID 2306856Notes

Reaction equation

HRID 2306856 reaction equation
[Cl:1][C:2]1[C:3]([CH:12]([N:20]=C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[C:3]([CH:12]([NH2:20])[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22629930HCID 22629930, compound

Product 1

HCID 69351932239113-23-6

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of the product from stage b) (1.29 g) in diethyl ether (5 ml) was added 1M hydrochloric acid (10 ml) at room temperature and the solution was stirred at room temperature for 2 hours. The mixture was filtered to give a solid, which was washed with water (15 ml) then ether (15 ml). Drying in vacuo gave the title product. Water was removed from the aqueous phase by azeotropic distillation with toluene (×3), to give further quantities of the title product.

Workup

  1. filtrationThe mixture was filtered
  2. customto give a solid, which
  3. washwas washed with water (15 ml)
  4. customDrying in vacuo

Sources & evidence

ORD record
ord-bb3e168c11bd4080b841a93b67be50ad
Source dataset
uspto-grants-2004_12
Patent number
US06828441B2

Reaction notes

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