Potassium Hydroxide → (3z)-2-[(Tert-butoxycarbonyl)amino]-5-cyano-2-methylpent-3-enoic acid potassium salt

HRID 2306882Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][C:9]([CH3:19])(/[CH:14]=[CH:15]\[CH2:16][C:17]#[N:18])[C:10]([O:12]C)=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[K+:21]>O>[K+:21].[C:1]([O:5][C:6]([NH:8][C:9]([CH3:19])(/[CH:14]=[CH:15]\[CH2:16][C:17]#[N:18])[C:10]([O-:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Conditions

Temperature: 50 °C

Procedure

The methyl (3Z)-2-[(tert-butoxycarbonyl)amino]-5-cyano-2-methylpent-3-enoate product of Example 1d is taken up in DI water. To this is added KOH and the reaction mixture is stirred at 50° C. for 3 h. It is then concentrated under reduced pressure to give the desired title product.

Workup

concentrationIt is then concentrated under reduced pressure

Sources & evidence

ORD record: ord-a7c492f0292a424f947c1736dbaf5101
Source dataset: uspto-grants-2004_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06828456B2

Reaction notes

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