Ethanesulfonic acid → n-{2-Tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1h-benzimidazol-5-yl}ethanesulfonamide esylate

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Reaction Steps

N-{2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}ethanesulfonamide (101 mg) was dissolved in iso-propylacetate (1.5 ml) at 42° C. and ethane sulphonic acid (20 μl, 95%) was added. Crystallisation started immediately. The slurry was left for three days before it was filtered off and washed with iso-propylacetate (3×200 μl). The product was dried at 40° C. under vacuum to yield 61 mg crystalline N-{2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}ethanesulfonamide esylate salt.

Provenance & Evidence