反应详情

To a round bottomed flask equipped with magnetic stirrer was added trans-N-[4-(2,4-bis{[tert-butyl(dimethyl)silyl]oxy}phenyl)cyclohexyl] methanesulfonamide (320 mg, 0.57 mmol) and 1,2-dichloroethane (50 ml). To the stirred solution was added trifluoroacetic acid (20 ml) and water (20 ml). The stirred reaction mixture was then heated under reflux for 18 hr and then cooled to room temperature. Toluene (70 ml) was added and the solvent removed in vacuo. Methanol (50 ml) was then added to the residue and the solvent removed under reduced pressure. The resulting oil was purified via flash column chromatography (SiO2, ethyl acetate/petroleum ether, 1:3, 1:2, then 1:1 v/v) to furnish the title product (115 mg, 71%) as a white solid. m/z (ES+) 286 (M+H+); δH(CD3OD) 1.52 (4H, m), 1.89 (2H, m), 2.13 (2H, m), 2.80 (1H, m), 3.00 (3H, s), 3.28 (1H, m), 6.27 (1H, d), 6.29 (1H, dd), 6.92 (1H, d).

1. customTo a round bottomed flask equipped with magnetic stirrer
2. customThe stirred reaction mixture
3. temperaturewas then heated
4. temperatureunder reflux for 18 hr
5. customthe solvent removed in vacuo
6. additionMethanol (50 ml) was then added to the residue
7. customthe solvent removed under reduced pressure
8. customThe resulting oil was purified via flash column chromatography (SiO2, ethyl acetate/petroleum ether, 1:3, 1:2