(2R)-1-aminopropan-2-ol → HCID 131724685, compound

HRID 2307226Notes

Reaction equation

HRID 2307226 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:11][N:10]([CH:12]([C:19]3C=CC=CC=3)C3C=CC=CC=3)[CH2:9]2)=[CH:4][CH:3]=1.[NH2:25][CH2:26][C@H:27]([OH:29])[CH3:28].C([O:32]CC)C.C1(C)C=CC=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:9][N:10]([CH2:12][C:19]([NH:25][CH2:26][C@H:27]([OH:29])[CH3:28])=[O:32])[CH2:11]2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 439938(2R)-1-aminopropan-2-olHCID 22238780Ether tolueneHCID 22605415HCID 22605415, compound

Product 1

HCID 131724685HCID 131724685, compound

Procedure

This compound was prepared from compound (6) and (R)-1-amino-2-propanol using the procedure outlined in Example 4, m.p. 92-93° C. (diethyl ether-toluene). Found: C, 58.97; H, 6.38; N, 9.96. C13H17CIN2O2.0.2PhCH3, requires C, 60.23; H, 6.48; N, 9.76%.

Sources & evidence

ORD record
ord-92e19dc736ec4b0c9d4e50aff83c457a
Source dataset
uspto-grants-2004_12
Patent number
US06831078B1

Reaction notes

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