Propargylamine → 3-(3,4-Dichlorophenyl)-N-(2-propynyl)azetidine carboxamide

HRID 2307228Notes

Reaction equation

HRID 2307228 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:12][N:11]([CH:13](C3C=CC=CC=3)C3C=CC=CC=3)[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH2:26]([NH2:29])[C:27]#[CH:28].C(C1C=CC(C2CN(C(NCC=C)=[O:45])C2)=CC=1)(C)(C)C>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:10][N:11]([C:13]([NH:29][CH2:26][C:27]#[CH:28])=[O:45])[CH2:12]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 3

HCID 239041PropargylamineHCID 226054023-(3,4-Dichlorophenyl)-1-(diphenylmethyl)azetidineHCID 226054033-(4-tert-butylphenyl)-N-(2-propenyl)azetidine-1-carboxamide

Product 1

HCID 226054203-(3,4-Dichlorophenyl)-N-(2-propynyl)azetidine carboxamide

Procedure

This compound was prepared from compound (26) and propargylamine using the procedure described for compound (12). mp. 105.5-107.5° C.

Sources & evidence

ORD record
ord-5b2344180fe945a4891656cc33d366b2
Source dataset
uspto-grants-2004_12
Patent number
US06831078B1

Reaction notes

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