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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2307235Generated: November 1, 2026

(2R)-1-aminopropan-2-ol → (R)-3-(3-(Trifluoromethyl)phenyl)-N-(2-hydroxypropyl)azetidine

https://huagongshe.com/reaction/2307235

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2R)-1-aminopropan-2-olHCID 439938—
Reactant3-(3-(Trifluoromethyl)phenyl)-1-(diphenylmethyl)azetidineHCID 22605395—
Reactant3-(4-tert-butylphenyl)-N-(2-propenyl)azetidine-1-carboxamideHCID 22605403—
Product(R)-3-(3-(Trifluoromethyl)phenyl)-N-(2-hydroxypropyl)azetidineHCID 53916089—

Reaction Steps

This compound was prepared from compound (38) and (R)-1-amino-2-propanol using the procedure described for compound (12). mp. 81-82° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06831078B1
Source datasetuspto-grants-2004_12
ORD IDord-235346725d044a8195bb7fe6094948a2
Source noteuspto-grants-2004_12