(2R)-1-aminopropan-2-ol → (R)-3-(3-(Trifluoromethyl)phenyl)-N-(2-hydroxypropyl)azetidine

HRID 2307235Notes

Reaction equation

HRID 2307235 reaction equation
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:4]=[C:5]([CH:9]2[CH2:12][N:11]([CH:13](C3C=CC=CC=3)[C:14]3C=CC=C[CH:15]=3)[CH2:10]2)[CH:6]=[CH:7][CH:8]=1.NC[C@H]([OH:32])C.C(C1C=CC(C2CN(C(NCC=C)=O)C2)=CC=1)(C)(C)C>>[F:1][C:2]([F:27])([F:26])[C:3]1[CH:4]=[C:5]([CH:9]2[CH2:12][N:11]([CH2:13][C@H:14]([OH:32])[CH3:15])[CH2:10]2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 439938(2R)-1-aminopropan-2-olHCID 226053953-(3-(Trifluoromethyl)phenyl)-1-(diphenylmethyl)azetidineHCID 226054033-(4-tert-butylphenyl)-N-(2-propenyl)azetidine-1-carboxamide

Product 1

HCID 53916089(R)-3-(3-(Trifluoromethyl)phenyl)-N-(2-hydroxypropyl)azetidine

Procedure

This compound was prepared from compound (38) and (R)-1-amino-2-propanol using the procedure described for compound (12). mp. 81-82° C.

Sources & evidence

ORD record
ord-235346725d044a8195bb7fe6094948a2
Source dataset
uspto-grants-2004_12
Patent number
US06831078B1

Reaction notes

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