Hydrazine hydrate (1:1) → HCID 22605819, compound

HRID 2307258Notes

Reaction equation

HRID 2307258 reaction equation
O.[NH2:2]N.C[N:5]([CH2:7][CH:8]1[C:17](=O)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[O:10][CH2:9]1)C>C(O)C>[N:2]1[NH:5][CH2:7][CH:8]2[CH2:9][O:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]=12

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 2821735HCID 2821735, compound

Product 1

HCID 22605819HCID 22605819, compoundYield 105.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Hydrazine monohydrate (7.2 g) was dissolved in ethanol (10 ml). Thereto was dropwise added a solution of 3-(N,N-dimethylaminomethyl)-4-chromanone (6.7 g) dissolved in ethanol (10 ml) in a nitrogen atmosphere at room temperature. The resulting mixture was refluxed for 4 hours with heating. The reaction mixture was poured into ice water. Extraction with chloroform was conducted, followed by drying and concentration, to obtain 6 g of a title compound.

Workup

  1. temperatureThe resulting mixture was refluxed for 4 hours
  2. temperaturewith heating
  3. extractionExtraction with chloroform
  4. customby drying
  5. concentrationconcentration

Sources & evidence

ORD record
ord-d6c16fbcbf204f83a8d2bdfaa5965a3a
Source dataset
uspto-grants-2004_12
Patent number
US06831083B2

Reaction notes

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