反应详情

A suspension of 2-chloro-5-nitro-pyridine (1.58 g, 10 mmol) in isopropanol (30 ml) was treated at rt with 1,2,3,4-tetrahydro-isoquinoline (2.6 g, 20 mmol). The resulting mixture was stirred for 3 hr. The precipitate was filtered, partitioned (AcOEt/H2O) and the organic phase dried (Na2SO4). After evaporation of the solvent the title compound was obtained as a yellow solid mass (1.4 g, 55%), MS: m/e=256 (M+H+).

1. filtrationThe precipitate was filtered
2. custompartitioned (AcOEt/H2O)
3. dry with materialthe organic phase dried (Na2SO4)
4. customAfter evaporation of the solvent the title compound
5. customwas obtained as a yellow solid mass (1.4 g, 55%), MS