tert-Butoxy bis(dimethylamino)methane → HCID 69844287, compound

HRID 2307328Notes

Reaction equation

HRID 2307328 reaction equation
[CH:1]1[CH:2]=[CH:3][N:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([C:23](=[O:25])[CH3:24])=[CH:19][CH:18]=3)=[O:16])[CH2:6][C:5]=12.C(O[CH:31](N(C)C)[N:32]([CH3:34])[CH3:33])(C)(C)C>ClCCl>[CH3:31][N:32]([CH3:34])[CH:33]=[CH:24][C:23]([C:20]1[CH:19]=[CH:18][C:17]([C:15]([N:7]2[C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[CH2:10][N:4]3[CH:3]=[CH:2][CH:1]=[C:5]3[CH2:6]2)=[O:16])=[CH:22][CH:21]=1)=[O:25]

Participants

4

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 9902046HCID 9902046, compound

Product 1

HCID 69844287HCID 69844287, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A reaction mixture of 1-[4-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepine-10-carbonyl)-phenyl]-ethanone (1.40 g), t-butoxy-bis-dimethylaminomethane (5.0 ml) and dichloromethane (10 ml) was stirred for 18 hours. The red-orange precipitate was filtered to yield the title compound (1.22 g), m.p. 203-205° C. Additional product (0.18 g) was isolated from the reaction mixture by concentration.

Workup

  1. filtrationThe red-orange precipitate was filtered

Sources & evidence

ORD record
ord-9eaad986bde843a78171f51a41b0ad0f
Source dataset
uspto-grants-2004_12
Patent number
US06831079B1

Reaction notes

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