Methyl (3-amino-4-nitrobenzenesulfonyl)acetate → Methyl (3,4-diaminobenzenesulfonyl)acetate

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Reaction Steps

14.3 500 mg of Raney nickel are added to a solution of 2.40 g (8.76 mmol) of methyl (3-amino-4-nitrobenzenesulfonyl)acetate in 50 ml of methanol, and the mixture is hydrogenated at room temperature and atmospheric pressure. The catalyst is filtered off, and the filtrate is evaporated, giving methyl (3,4-diaminobenzenesulfonyl)acetate as a yellow solid; ESI 245.

Provenance & Evidence