Thionyl Chloride → 6-(1-methyl-1H-pyrazol-4-yl)pyridine-3-carbonyl chloride

HRID 2307351Notes

Reaction equation

HRID 2307351 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[CH:11][C:10]([C:13]([OH:15])=O)=[CH:9][CH:8]=2)[CH:4]=[N:3]1.S(Cl)([Cl:18])=O>>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[CH:11][C:10]([C:13]([Cl:18])=[O:15])=[CH:9][CH:8]=2)[CH:4]=[N:3]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 3953327HCID 3953327, compound

Product 1

HCID 226054536-(1-methyl-1H-pyrazol-4-yl)pyridine-3-carbonyl chloride

Procedure

A suspension of 6-(1-methyl-1H-pyrazol-4-yl)pyridine-3-carboxylic acid (0.48 g) in thionyl chloride (5.0 ml) was stirred at room temperature for 2 hours. The volatile material was removed under reduced pressure to afford 6-(1-methyl-1H-pyrazol-4-yl)pyridine-3-carbonyl chloride as a solid, which was utilized without further purification.

Workup

  1. customThe volatile material was removed under reduced pressure

Sources & evidence

ORD record
ord-f45e4fe917de4560b1c572e5040d1891
Source dataset
uspto-grants-2004_12
Patent number
US06831079B1

Reaction notes

Loading…