Hydrochloric Acid → HCID 22605435, compound

HRID 2307392Notes

Reaction equation

HRID 2307392 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][N:15]([CH3:17])[CH:16]=2)[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][N:15]([CH3:17])[CH:16]=2)[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86758811HCID 86758811, compound

Product 1

HCID 22605435HCID 22605435, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-chloro-4-(1-methyl-1H-pyrazol-4-yl)-benzoic acid, methyl ester (6.25 ) from Example 113 in methanol (80 ml) was added 1N sodium hydroxide (30 ml). The reaction was heated under reflux for one hour. The volume of solvent was reduced in vacuo by three quarters and the residue treated with 2N hydrochloric acid at 0° C. A precipitate was filtered and dried in vacuo to yield 5.84 g the title compound, MS m/z: 237 [M+H]+.

Workup

  1. temperatureThe reaction was heated
  2. temperatureunder reflux for one hour
  3. filtrationA precipitate was filtered
  4. customdried in vacuo

Sources & evidence

ORD record
ord-44620d6ce251439f86ce272f4600f094
Source dataset
uspto-grants-2004_12
Patent number
US06831079B1

Reaction notes

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