Hydrochloric Acid → 1-(3-Morpholin-4-yl-phenyl)ethylamine hydrochloride

HRID 2307419Notes

Reaction equation

HRID 2307419 reaction equation
C(OC(=O)[NH:7][CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[CH:11]=1)[CH3:9])(C)(C)C.[ClH:23]>CO>[ClH:23].[N:16]1([C:12]2[CH:11]=[C:10]([CH:8]([NH2:7])[CH3:9])[CH:15]=[CH:14][CH:13]=2)[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69850623[1-(3-Morpholin-4-yl-phenyl)ethyl]carbamic acid tert-butyl ester

Product 1

HCID 226056291-(3-Morpholin-4-yl-phenyl)ethylamine hydrochlorideYield 84.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of [1-(3-morpholin-4-yl-phenyl)ethyl]carbamic acid tert-butyl ester (1 g, 3.27 mmol) in methanol (3 mL) was added hydrochloric acid (1.0 M in ethyl ether) (13.1 mL, 13.1 mmol) and the reaction mixture was stirred at room temperature for 10 hours. The reaction mixture was concentrated under vacuum to provide the title compound as pale yellow solid (0.67 g, quantitative yield) which was used for next step without any further purification.

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-34bafb1d17e24a42a3d1b03f22530a72
Source dataset
uspto-grants-2004_12
Patent number
US06831080B2

Reaction notes

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