反应详情

A mixture of 1-(2-fluoro-5-nitro-phenyl)ethanone (7.3 g) and 5% Pt(S)/C (730 mg) in ethanol (50 mL) was hydrogenated at 50 psi for 20 hours. The reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo. The residue was purified by silica gel flash chromatography (33% ethyl acetate in hexane) to give the title compound as a solid (3.56 g).

1. filtrationThe reaction mixture was filtered through Celite
2. concentrationthe filtrate was concentrated in vacuo
3. customThe residue was purified by silica gel flash chromatography (33% ethyl acetate in hexane)