Hydrochloric Acid → HCID 69919574, compound

HRID 2307458Notes

Reaction equation

HRID 2307458 reaction equation
C(OC(=O)[NH:7][CH2:8][C@@H:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH:21]([NH:23][C:24](=[O:35])[CH:25]=[CH:26][C:27]3[CH:32]=[CH:31][C:30]([F:33])=[C:29]([F:34])[CH:28]=3)[CH3:22])[CH:16]=2)[CH2:10]1)(C)(C)C.Cl>CO>[NH2:7][CH2:8][CH:9]1[O:14][CH2:13][CH2:12][N:11]([C:15]2[CH:16]=[C:17]([C@@H:21]([NH:23][C:24](=[O:35])[CH:25]=[CH:26][C:27]3[CH:32]=[CH:31][C:30]([F:33])=[C:29]([F:34])[CH:28]=3)[CH3:22])[CH:18]=[CH:19][CH:20]=2)[CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69852395HCID 69852395, compound

Product 1

HCID 69919574HCID 69919574, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The solution of (S)-[4-(3-{1-[3-(3,4-difluoro-phenyl)-acryloylamino]-ethyl}-phenyl)-morpholin-2-ylmethyl]-carbamic acid tert-butyl ester, Example 125 (about 24 mg), and hydrochloric acid (1.0M solution in diethyl ether) (0.3 ml) in methanol (0.3 ml) was stirred at room temperature overnight. Concentrated under vacuum and sticky oil was filtered through 2 g anion-exchange cartridge with methanol. Filtrate was concentrated under vacuum and the title compound was obtained as pale yellow solid (quantitative yield).

Workup

  1. customwas stirred at room temperature overnight
  2. concentrationConcentrated under vacuum and sticky oil
  3. filtrationwas filtered through 2 g anion-exchange cartridge with methanol
  4. concentrationFiltrate was concentrated under vacuum

Sources & evidence

ORD record
ord-7df05f997d68450aa93d8de61560ab17
Source dataset
uspto-grants-2004_12
Patent number
US06831080B2

Reaction notes

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