Ethyl 3-iodobenzoate → 3'-Hydroxy-biphenyl-3-carboxylic acid ethyl ester

HRID 2307544Notes

Reaction equation

HRID 2307544 reaction equation
COC[O:4][C:5]1[CH:6]=[C:7](B(O)O)[CH:8]=[CH:9][CH:10]=1.I[C:15]1[CH:16]=[C:17]([CH:23]=[CH:24][CH:25]=1)[C:18]([O:20][CH2:21][CH3:22])=[O:19]>>[OH:4][C:5]1[CH:6]=[C:7]([C:24]2[CH:25]=[CH:15][CH:16]=[C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:23]=2)[CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 143542Ethyl 3-iodobenzoateHCID 22606941(3-(Methoxymethoxy)phenyl)boronic acid

Product 1

HCID 226068863'-Hydroxy-biphenyl-3-carboxylic acid ethyl ester

Procedure

In a manner similar to that of Example 1(h), by reaction of 2 g (13.3 mmol) of 3-methoxymethoxyphenylboronic acid with 1.83 mL (11 mmol) of ethyl 3-iodobenzoate, 1.9 g (72%) of the expected ethyl ester are obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-4e20bf254a6f4736904b5d3490b409fd
Source dataset
uspto-grants-2004_12
Patent number
US06831106B1

Reaction notes

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