Potassium Carbonate → Methyl 3'-hydroxy-2,6-dimethylbiphenyl-4-carboxylate

HRID 2307569Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2307569
COC[O:4][C:5]1[CH:6]=[C:7](B(O)O)[CH:8]=[CH:9][CH:10]=1.[CH3:14][C:15]1[CH:16]=[C:17]([CH:22]=[C:23]([CH3:33])[C:24]=1OS(C(F)(F)F)(=O)=O)[C:18]([O:20][CH3:21])=[O:19].C(=O)([O-])[O-].[K+].[K+]>CO.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[OH:4][C:5]1[CH:6]=[C:7]([C:24]2[C:23]([CH3:33])=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][C:15]=2[CH3:14])[CH:8]=[CH:9][CH:10]=1

Komponenten

6

Edukt 3

HCID 11430Potassium CarbonateHCID 11849880Methyl 3,5-dimethyl-4-(((trifluoromethyl)sulfonyl)oxy)benzoateHCID 22606941(3-(Methoxymethoxy)phenyl)boronic acid

Produkt 1

HCID 22606868Methyl 3'-hydroxy-2,6-dimethylbiphenyl-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418397HCID 178418397, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

In a manner similar to that of Example 1(h), by reaction of 4.48 g (24 mmol) of 3-methoxymethoxyphenylboronic acid (described in Example 1(g)) with 7 g (22.4 mmol) of methyl 3,5-dimethyl-4-trifluoromethanesulphonyloxybenzoate, 24 mL of 2M potassium carbonate and 1.29 g (1.1 mmol) of tetrakis(triphenylphosphine)palladium, followed by deprotection in methanol, the desired product is obtained.

Quellen und Nachweise

ORD-Eintrag
ord-c2818fd080654b61a9a222027e7dcddd
Quelldatensatz
uspto-grants-2004_12
Patentnummer
US06831106B1

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