HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Methyl 3'-hydroxy-2,6-dimethylbiphenyl-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 3,5-dimethyl-4-(((trifluoromethyl)sulfonyl)oxy)benzoate | HCID 11849880 | — |
| Reactant | (3-(Methoxymethoxy)phenyl)boronic acid | HCID 22606941 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 3'-hydroxy-2,6-dimethylbiphenyl-4-carboxylate | HCID 22606868 | — |
Reaction Steps
In a manner similar to that of Example 1(h), by reaction of 4.48 g (24 mmol) of 3-methoxymethoxyphenylboronic acid (described in Example 1(g)) with 7 g (22.4 mmol) of methyl 3,5-dimethyl-4-trifluoromethanesulphonyloxybenzoate, 24 mL of 2M potassium carbonate and 1.29 g (1.1 mmol) of tetrakis(triphenylphosphine)palladium, followed by deprotection in methanol, the desired product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06831106B1 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-c2818fd080654b61a9a222027e7dcddd |
| Source note | uspto-grants-2004_12 |