4'-Trifluoromethyl-biphenyl-3-carbaldehyde → N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]-N-{[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methyl}amine

HRID 2307643Notes

Reaction equation

HRID 2307643 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH:15]=O)[CH:10]=2)=[CH:5][CH:4]=1.[C@@H:19]1([NH2:29])[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][CH2:20]1>>[C@@H:19]1([NH:29][CH2:15][C:11]2[CH:10]=[C:9]([C:6]3[CH:7]=[CH:8][C:3]([C:2]([F:18])([F:17])[F:1])=[CH:4][CH:5]=3)[CH:14]=[CH:13][CH:12]=2)[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 27827114'-Trifluoromethyl-biphenyl-3-carbaldehydeHCID 70580741-Aminotetralin, (S)-

Product 1

HCID 69722555N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]-N-{[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methyl}amine

Procedure

4′-(Trifluoromethyl)[1,1′-biphenyl]-3-carbaldehyde and (1S)-1,2,3,4-tetrahydro-1-naphthalenylamine were processed as described in Example 1A to provide the title compound.

Sources & evidence

ORD record
ord-7060e26b6a1f4ae7bf331c0a2a69e906
Source dataset
uspto-grants-2004_12
Patent number
US06831193B2

Reaction notes

Loading…