3-Hydroxybenzaldehyde → 3-(Cyclohexyloxy)benzaldehyde

HRID 2307667Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[CH:10]1(O)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>>[CH:10]1([O:1][C:2]2[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=2)[CH:5]=[O:6])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

Reactant 2

HCID 1013-Hydroxybenzaldehyde

HCID 7966Cyclohexanol

Product 1

HCID 226080673-(Cyclohexyloxy)benzaldehyde

Procedure

3-Hydroxybenzaldehyde, purchased from Acros, and cyclohexanol were processed under Mitsunobu conditions, as described in Saccomano, et al., J. Med. Chem. 34, (1991) 291-298, to provide the title compound.

Sources & evidence

ORD record: ord-094e8fae9d2545b5ade52bf8c4fadb18
Source dataset: uspto-grants-2004_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06831193B2

Reaction notes

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