Ethylparaben → 4-Ethoxycarbonylphenoxy-2'-pyridylmethane

HRID 230772Notes

Reaction equation

Cl.Cl[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1.[OH:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][CH:12]=1>>[N:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[CH2:3][O:10][C:11]1[CH:12]=[CH:13][C:14]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:15][CH:16]=1

Participants

Reactant 2

HCID 8434Ethylparaben

HCID 23392Picolyl chloride hydrochloride

Product 1

HCID 1911264-Ethoxycarbonylphenoxy-2'-pyridylmethaneYield 83.7%

Procedure

2-Chloromethylpyridine hydrochloride (500 mg) and ethyl 4-hydroxybenzenecarboxylate (506 mg) were processed in the same manner as in Production Example 1-1 to obtain the entitled compound (656 mg).

Sources & evidence

ORD record: ord-b469d348c1e04250a5471fd0753fe8d4
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07566781B2

Reaction notes

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