2-Amino-4-chloropyrimidine → HCID 69917682, compound

HRID 2307792Notes

Reaction equation

HRID 2307792 reaction equation
[C:1]([O:5][C:6](=[O:34])[NH:7][C@@H:8]([CH2:24][C:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[NH:27][CH:26]=1)[CH2:9][O:10][C:11]1[CH:12]=[N:13][CH:14]=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([NH2:23])[CH:18]=2)[CH:16]=1)([CH3:4])([CH3:3])[CH3:2].Cl[C:36]1[CH:41]=[CH:40][N:39]=[C:38]([NH2:42])[N:37]=1>CCO>[C:1]([O:5][C:6](=[O:34])[NH:7][C@@H:8]([CH2:24][C:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[NH:27][CH:26]=1)[CH2:9][O:10][C:11]1[CH:12]=[N:13][CH:14]=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:36]3[CH:41]=[CH:40][N:39]=[C:38]([NH2:42])[N:37]=3)[CH:18]=2)[CH:16]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 2233322-Amino-4-chloropyrimidineHCID 69918507HCID 69918507, compound

Product 1

HCID 69917682HCID 69917682, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of Example 121A (0.07 g, 0.153 mmol) and 4-chloro-2-pyrimidinylamine (0.021 g, 0.163 mmol) was dissolved in EtOH (1 mL). The mixture was heated to 80° C. overnight then cooled and evaporated. The product was used without further purification.

Workup

  1. temperaturethen cooled
  2. customevaporated
  3. customThe product was used without further purification

Sources & evidence

ORD record
ord-c29fc9ef014f4fab88ef18c21893af61
Source dataset
uspto-grants-2004_12
Patent number
US06831175B2

Reaction notes

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