Phosphorus oxychloride → 4,7-Dichloropyrido[2,3-d]pyrimidine

HRID 2307794Notes

Reaction equation

HRID 2307794 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:10](O)=[N:9][CH:8]=[N:7][C:6]=2[N:12]=1.P(Cl)(Cl)([Cl:15])=O>>[Cl:15][C:10]1[C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[N:12][C:6]=2[N:7]=[CH:8][N:9]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178518043HCID 178518043, compound

Product 1

HCID 226077594,7-Dichloropyrido[2,3-d]pyrimidineYield 73%

Procedure

A mixture of Example 140C (1 g, 5.5 mmol) in phosphorus oxychloride (40 mL) was refluxed for 2 h then cooled and evaporated. The residue was taken into ethyl acetate (75 ml), washed with saturated sodium bicarbonate (50 ml) water (50 ml) and brine (50 ml). The ethyl acetate was evaporated to yield 0.8 g of product (73%).

Workup

  1. temperaturethen cooled
  2. customevaporated
  3. washwashed with saturated sodium bicarbonate (50 ml) water (50 ml) and brine (50 ml)
  4. customThe ethyl acetate was evaporated

Sources & evidence

ORD record
ord-2b7a77ded1d942b688d3a870805edb11
Source dataset
uspto-grants-2004_12
Patent number
US06831175B2

Reaction notes

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