Aniline → (6-Bromo-cinnolin-4-yl)-phenyl-amine

HRID 2307811Notes

Reaction equation

HRID 2307811 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[N:7][CH:6]=[C:5]2Cl.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[N:7][CH:6]=[C:5]2[NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 6115AnilineHCID 124480786-Bromo-4-chlorocinnoline

Product 1

HCID 22607560(6-Bromo-cinnolin-4-yl)-phenyl-amineYield 62%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of Example 34D (500 mg; 2.5 mmol) and aniline (1.5 mL) in MeOH (11 mL) was stirred at r.t. for 2.5 hrs, the resulting precipitate was collected, rinsed with water and dried under vacuum to provide the desired product (400 mg; 62%).

Workup

  1. customthe resulting precipitate was collected
  2. washrinsed with water
  3. customdried under vacuum

Sources & evidence

ORD record
ord-0f9f53e939e048faaae75e14c13c124a
Source dataset
uspto-grants-2004_12
Patent number
US06831175B2

Reaction notes

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