Methanol → Methyl 4-bromo-2-methylbenzoate

HRID 2307812Notes

Reaction equation

HRID 2307812 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([CH3:11])[CH:3]=1.[CH3:12]O>Cl>[CH3:12][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([Br:1])=[CH:3][C:4]=1[CH3:11]

Participants

4

Reactant 2

HCID 887MethanolHCID 995704-Bromo-2-methylbenzoic acid

Product 1

HCID 22031226Methyl 4-bromo-2-methylbenzoateYield 100%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidCatalyst

Procedure

A solution of 4-bromo-2-methyl benzoic acid (1.0 g; 4.7 mmol) in MeOH (24 mL) with 20 drops conc. HCl was heated at reflux for 6 hrs. the concentrated to provide the desired product (1.1 g; 100%).

Workup

  1. temperatureat reflux for 6 hrs
  2. concentrationthe concentrated

Sources & evidence

ORD record
ord-c64be67cc49c4814978b2d21dcff4b2a
Source dataset
uspto-grants-2004_12
Patent number
US06831175B2

Reaction notes

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