反应详情

温度

145 °C

A mixture of methyl 4-bromomethyl-3-fluorobenzenecarboxylate (240 mg) and triethyl phosphite (0.32 mL) was heated at 145° C. for 2 hours. The reaction solution was purified through silica gel column chromatography (ethyl acetate/methanol=9/1) to obtain the entitled compound (300 mg).

1. customThe reaction solution was purified through silica gel column chromatography (ethyl acetate/methanol=9/1)