HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 230782Generated: October 25, 2026
Triethyl phosphite → Methyl 4-[(diethoxyphosphoryl)methyl]-3-fluorobenzoate
https://huagongshe.com/reaction/230782
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethyl phosphite | HCID 31215 | — |
| Reactant | Methyl 4-(bromomethyl)-3-fluorobenzoate | HCID 18766370 | — |
| Product | Methyl 4-[(diethoxyphosphoryl)methyl]-3-fluorobenzoate | HCID 23498922 | — |
Reaction Steps
A mixture of methyl 4-bromomethyl-3-fluorobenzenecarboxylate (240 mg) and triethyl phosphite (0.32 mL) was heated at 145° C. for 2 hours. The reaction solution was purified through silica gel column chromatography (ethyl acetate/methanol=9/1) to obtain the entitled compound (300 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07566781B2 |
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| Source dataset | uspto-grants-2009_07 |
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| ORD ID | ord-74b227b3be194ed780e3d63d6ff7f6c1 |
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| Source note | uspto-grants-2009_07 |
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