HCID 90712428, compound → HCID 69917680, compound

HRID 2307827Notes

Reaction equation

HRID 2307827 reaction equation
[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([C:17]3[CH:18]=[N:19][CH:20]=[C:21]([O:23][CH:24]([CH2:35][N:36]=[N+]=[N-])[CH2:25][C:26]4[C:34]5[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=5)[NH:28][CH:27]=4)[CH:22]=3)=[CH:14][CH:15]=2)[C:10]([CH3:39])=[N:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([C:17]3[CH:18]=[N:19][CH:20]=[C:21]([O:23][CH:24]([CH2:35][NH2:36])[CH2:25][C:26]4[C:34]5[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=5)[NH:28][CH:27]=4)[CH:22]=3)=[CH:14][CH:15]=2)[C:10]([CH3:39])=[N:9]1)=[O:7])([CH3:2])([CH3:4])[CH3:3]

Participants

4

Reactant 1

HCID 90712428HCID 90712428, compound

Product 1

HCID 69917680HCID 69917680, compoundYield 97.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of Example 406A (480 mg) in ethanol was added 10% Pd/C (160 mg) under nitrogen. This suspension was purged with hydrogen (3 circles) and was stirred under hydrogen (balloon) for 4 h. The solid material was filtered off and the filtrate was concentrated to give the desired product (443 mg, 97%). MS (APCI) m/z 498 (M+1)+.

Workup

  1. customThis suspension was purged with hydrogen (3 circles)
  2. filtrationThe solid material was filtered off
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-cba0dcdebb3f4402bd62eccf108a40f9
Source dataset
uspto-grants-2004_12
Patent number
US06831175B2

Reaction notes

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