Hydrochloric Acid → HCID 86615939, compound

Participants

Reaction Steps

60% sodium hydride (184 mg) was added to a DMF solution (8.4 mL) of 4-(diethoxyphosphorylmethyl)benzenecarboxylic acid (636 mg) produced according to JP-A 11-60537 at 0° C., and stirred for 1 hour, and then a DMF solution (10 mL) of the compound (296 mg) obtained in Production Example T-3 was added thereto at 0° C. and stirred for 5 hours. Water was added to the reaction liquid, its pH was controlled to be 2 with 4 N hydrochloric acid, and the precipitated matter was taken out through filtration to obtain the entitled compound (464 mg) as a yellow solid.

Provenance & Evidence