Hydrochloric Acid → HCID 86615939, compound

HRID 230784Notes

Reaction equation

HRID 230784 reaction equation
[H-].[Na+].C[N:4]([CH:6]=O)[CH3:5].C(OP([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([OH:25])=[O:24])=[CH:19][CH:18]=1)(OCC)=O)C.[ClH:26]>O>[Cl:26][C:5]1[N:4]=[CH:6][C:18](/[CH:19]=[CH:16]/[C:17]2[CH:18]=[CH:19][C:20]([C:23]([OH:25])=[O:24])=[CH:21][CH:22]=2)=[CH:17][CH:16]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6228Dimethylformamide2×HCID 24758Sodium hydrideHCID 137458014-[(Diethoxyphosphoryl)methyl]benzoic acid

Product 1

HCID 86615939HCID 86615939, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

60% sodium hydride (184 mg) was added to a DMF solution (8.4 mL) of 4-(diethoxyphosphorylmethyl)benzenecarboxylic acid (636 mg) produced according to JP-A 11-60537 at 0° C., and stirred for 1 hour, and then a DMF solution (10 mL) of the compound (296 mg) obtained in Production Example T-3 was added thereto at 0° C. and stirred for 5 hours. Water was added to the reaction liquid, its pH was controlled to be 2 with 4 N hydrochloric acid, and the precipitated matter was taken out through filtration to obtain the entitled compound (464 mg) as a yellow solid.

Workup

  1. customproduced
  2. customaccording to JP-A 11-60537 at 0° C.
  3. additionwas added
  4. stirringat 0° C. and stirred for 5 hours
  5. filtrationthe precipitated matter was taken out through filtration

Sources & evidence

ORD record
ord-7e8a13e826af40b5967bae5eaf065bee
Source dataset
uspto-grants-2009_07
Patent number
US07566781B2

Reaction notes

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