1,1-Dimethoxyethyl(dimethyl)amine → HCID 12146677, compound

HRID 2307845Notes

Reaction equation

HRID 2307845 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[N:20]=[CH:19][C:18]([C:21](=[S:23])[NH2:22])=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.CO[C:28](OC)([N:30]([CH3:32])[CH3:31])[CH3:29]>>[CH3:31][N:30]([CH3:32])[C:28](=[N:22][C:21]([C:18]1[CH:19]=[N:20][C:15]([N:12]2[CH2:11][CH2:10][N:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:24])[F:25])[CH:4]=3)[CH2:14][CH2:13]2)=[CH:16][CH:17]=1)=[S:23])[CH3:29]

Participants

3

Reactant 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 22602786HCID 22602786, compound

Product 1

HCID 12146677HCID 12146677, compound

Procedure

A mixture of intermediate 4 (0.013 mol) and 1,1-dimethoxy-N,N-dimethyl-ethanamine (0.021 mol) was allowed to stand overnight and then used without further purification, yielding N-[1-(dimethylamino)ethylidene]-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-3-pyridinecarbothioamide (intermediate 5).

Workup

  1. customused without further purification

Sources & evidence

ORD record
ord-1d3297f8cf5a4e3f838039c10d843f35
Source dataset
uspto-grants-2004_12
Patent number
US06833369B2

Reaction notes

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